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Generally, dose assortment for an aged individual needs to be careful, commonly starting off at the reduced end on the dosing selection, reflecting the increased frequency of lowered hepatic, renal or cardiac function, and of concomitant ailment or other drug therapy.
Accidental ingestion of codeine sulfate, especially by small children, may end up in a fatal overdose of codeine.
Promethazine (promethazine HCl) Syrup should be used for the duration of pregnancy provided that the prospective profit justifies the possible chance into the fetus.
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Prolonged-time period animal scientific tests have not been performed to evaluate the carcinogenic prospective of promethazine, nor are there other animal or human facts regarding carcinogenicity, mutagenicity, or impairment of fertility with this drug. Promethazine was nonmutagenic from the Salmonellatest technique of Ames.
Infants born dependent on pattern-forming medicine might require health-related cure for quite a few weeks. Explain to your physician For anyone who is pregnant or system to be read more pregnant.
Promethazine is metabolized through the liver to various compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites showing up during the urine.
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Getting codeine and guaifenesin with other medications that make you sleepy or sluggish your breathing could potentially cause unsafe Negative effects or death.
Slowed Gut Movement. Paralytic ileus is often a form of ileus the place your intestines are struggling to move foodstuff as a result of them. Promethazine/codeine might make this affliction worse.
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